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Wang Xuan

Wang Xuan

 

Xuan WangPh.DProfessor

Tel: +86-10-82806818(O)+86-10-82801711L

Fax:+86-10-82806818(O)

E-mail: xuanwang6818@bjmu.edu.cn

Address: Department of Chemical Biology School of Pharmaceutical SciencesPeking University, Beijing 100191, China

Education

Mar.1986~Mar.1989 

Ph.D. degree at Toyama Medical and Pharmaceutical University, Major in Pharmacognosy

Nov.1985~Mar.1986  

Advanced students at Toyama Medical and Pharmaceutical University (Japan),Major in Pharmacognosy

Sep.1982~Oct. 1985

Master’s degree at School of Pharmaceutical Sciences, Beijing Medical University, Major in Pharmacognosy

Oct.1978~Jul.1982   

B.Sc. degree at School of Pharmaceutical Sciences, Beijing Medical University, Major in Pharmacy

Professional Background

Mar.1999~present   

Professor of Pharmaceutical Analysis, School of Pharm. Scien. Peking Univ. (Beijing Med.Univ.)

Dec. 2010~present 

The Member of the 10th Pharmacopoeia Commission of the People’s Republic of China

Jun. 1998~Mar.1999  

Professor of Pharmacognosy, Beijing Med. Univ.

Apr. 1989~Sep.1989 

Visiting Researcher at Research Institute for Wakan-Yaku, Toyama Med. and Pharm. Univ.

Oct.1985~Nov.1985  

Assistant, Department of Pharmacognosy, School of Pharmaceutical Sciences, Beijing Medical University

Teaching

l  Courses:  Advanced pharmaceutical analysis(for graduate students)

                       Biopharmaceutical analysis(for graduate students)

                      pharmaceutical analysis(for undergraduate students)

l  Textbook:  < pharmaceutical analysis>, China Medical Science Press, Sept. 2010,

                        < pharmaceutical analysis>, People’s Medical Publishing House, 2011

                        < pharmaceutical analysis exercises and learning guide>, China Medical Science Press, Sept. 2010

Research Interests

l  Research experience

Responsible for and participate in research projects:the General Program and Key Program of National Natural Science Foundation of China”, “National Program on Key Basic Research Project of China (973 Program)”;“National Programs for Science and Technology Development”, “National Key Technology Research and Development Program of theMinistry of Science and Technology of China”.

l  Research Interests

1. Pharmaceutical analysis in biological samples;

2. Quality evaluation of Chinese traditional medicines

Honor and Awards

2006, won the First Prize of Scientific and Technological awarded by China Association of Chinese Medicine.

1997, won the Third Prize of the State Scientific and Technological Progress.

1996, be won the First Prize of Scientific and Technological Progress awarded by   

          the State Administration of Traditional Chinese Medicine.

Representative Publications

1. Sesquiterpene and Aristolochic Acid Derivatives from Thottea hainanensis Helvetica Chimica Acta – Vol. 93:354-360 (2010), Shi-Wen DongXuan Wang*, Ming-Ying Shang, Chao-Mei Ma, Shu-Xiang Zhang, Xiao-Wei Lia, Min-Juan Xu, Shao-Qing Cai* , and Tsuneo Namba

2. 5–Methoxyaristololactam I, the First Natural 5–Substituted Aristololactam from Asarum ichangense Natural Product Communications, 2011, 6 ( 1): 11 - 14   Bai–Bo Xie, Ming–Ying Shanga Kuo–Hsiung Lee,  Xuan Wang, Katsuko Komatsuc  and Shao–Qing Cai

3. Chemical constituents fromSaruma henryi. J Chin Pharm Scien. 2009,182):110~114 Shi-Wen Dong, Ming-Ying Shang, Xuan Wang*, Shu-Xiang Zhang, Chen Li, Shao-Qing Cai

4. A new aristololactam from Asarum maximum  J Chin Pharm Scien. 2009,18183~185. Jie Yu, Chao-Mei Ma , Chang-Feng Long , Xuan Wang , Ming-Ying Shang , Shao-Qing Cai , Masao Hattori , Tsuneo Namba 

5. Pharmacokinetica studies of aristolochic acid-I and -II in rats after intragastricaladministration of Radix Aristolochiae and Muskone J Chin Pharm Scien. 2009,1879~83.Pema Dolma, Dong-HuiYang , Jie Yu, Xuan Wang, Shao-Qing Cai 

6. A new aristolochic acid derivative from Asarum himalaicum. Acta Pharmaceutica Sinica 2011, 46 (2): 188-192 XIE Bai-bo, SHANG Ming-ying*, WANG Xuan, CAI Shao-qing*, Kuo-hsiung LEE

7. Chemical Constituent from the Fruit of  Aristolochia contorta. China J of Chinese Materia Medica, 2010,3521: 2862-2865. Yu-Qiong XuMing-YingShangYue-WeiGe XuanWangShao-QingCai

8. Aristolochic Acid Nephropathy: Variation in Presentation and Prognosisnephrol dial transplant, 2011Li Yang 1& and Tao Su 1&, Xiao-Mei Li 1*, Xuan Wang2, Shao-Qing Cai2, Li-Qiang Meng1, Wan-Zhong Zou 3, Hai-Yan Wang1

9. Anti-inflammatory and anti-nociceptive effects in mice of the water and ethanol extracts of the roots and rhizomes of Asarum heterotropoides var. mandshuricum, China J of Chinese Materia Medica, 20093417:32~37 Xiong Yulan, Jing Yu, Shang Mingying, Li Changling, Ye Jia, Wang Xuan, Cai Shaoqing

10. Production, Characterization of a Monoclonal Antibody against Aristolochic Acid-II and Development of its Assay System. The American Journal of Chinese Medicine, Vol. 36, No. 2, 425– 436, 2008. Min Tian, Hiroyuki Tanaka, Ming-Ying Shang, Seiko Karashima, Zhi Chao, Xuan Wang, Shao-Qing Cai and Yukihiro Shoyama

11. Cytotoxic activity of some Asarum plants. Fitoterapia, 79 (2008) 293–297.Shao-Qing Cai,*,Jie YuXuan Wang , Rui-Qing Wang, Fu-Xiang Ran, Ming-Ying Shang, Jing-Rong Cui, Katsuko Komatsu, Tsuneo Namba

12. Observation of penetrationdistribution and accumulation in human renal proximal tubular epithelial cells by aristololactam-IChina J of Chinese Materia Medica, 2008337:793~797. SHANG Pu, WANG Xuan*, LI Xiao-Mei*, TANG Jia-Wei, CAI Shao-Qing

13. Studies on sofid phase extraction method of aristolochic acids and aristololactams in rat urineChina J of Chinese Materia Medica, 20073224:2613~2619.ZHAO DianhongQU LeiWANG Xuan*LI Xiao meiXU Jun yuCAI Shao qing

14. Several Factors Affecting the HPLC-Fingerprinting of Panax notoginseng.  Chin J Nat Med, 2(1): 33~41,J.LI, X.WANG, F.-Y. MA, X.-H. JIA, S.Q.CAI*, X.-M. LIANG and  K.KOMATSU

15. Cytotoxicity of Phenanthrenes Extracted from Aristolochia contorta in Human Proximal Tubular Epithelial Cell Line. Nephron Exp Nephrol 2006, 103:e95~ e102. Yu-jie WenTao SuJia-wei TangCui-ying ZhangXuang WangShao-qing CaiXiao-mei Li*

16. Simultaneous Determination of Five Aristolochic Acids and Two Aristololactams in Aristolochia Plants by High performance Liquid Chromatography. Biomedical Chromatography, 2006, 20309~318 C.-Y.Zhang, X. Wang, M.-Y. Shang, J. Yu, Y.-Q Xu, Z.-G. Li, L.-C. Lei, X.-M. Li, S.-Q. Cai1 * and T. Namba

17. New aristolochic acid, aristololactam and renal cytotoxic constituents from the stems and leaves of Aristolochia contorta . DIE PHARMAZIE , 2005, 60(10):  785~788. C.-Y. Zhang, X. Wang, T. Su, C.-M. Ma, Y.-J. Wen, M.-Y.

Shang, X.-M. Li, G.-X. Liu, S.-Q. Cai *

18. Affection of Different Preparations on the Content of Toxic Constituents in Traditional Chinese Medicines, Examplified with Caulis Aristolochiae Manshuriensis. China J of Chinese Materia Medica, 2005 3011):835~839. C.-Y. Zhang, X. Wang, M.-Y. Shang, J.Yu, J.-Y. Xu, Z.-G. Xu,X.-M. Li, S.-Q. Cai and T. Namba

19. Analysis of the Constituents in the Chinese Drug Notoginseng by Liquid Chromatography-Electrospray Mass Spectrometry. J Chin Pharm Scien2004134):225~237. J.-H. Liu , X. Wang*, S.-Q. CaiK. Komatsu and T. Namba

20.Cellular Mechanism of Renal Proximal Tubular Epithelial Cell Injury Induced by Aristolochic Acid I and Aristolalactam I. J of Peking Univ (Health Sciences), 200436(1):36~40.    B. Li, X.-M. Li, C.-Y. Zhang, X. Wang and S.-Q. Cai

21. Shao-Qing Cai,  Xuan Wang(Chief Editor). <Species Systematization and Quality Evaluation of Commonly Used Chinese Traditional Drugs>,  North-China Edition Vol.VIBeijing Medical University Press2003.