1.  抗HIV-1单靶点及双靶点抑制剂的设计合成及活性评估，

2. 基于对宿主STING蛋白激动剂的研究，从而寻找抗HIV病毒新思路，

3. 抗HBV病毒药物的设计合成及活性评估。

近年参与及主持的科研项目：

 1. 国家自然科学基金“环庚骈嘧啶类新型非核苷抗艾滋病药物的设计合成及活性研究”

 2. 博士点基金“环更并嘧啶类新型非核苷抗艾滋病药物的设计合成和活性研究”

 3. 国家自然科学基金“基于DAPY/S-DABO结构的新型非核苷类逆转录酶抑制剂的研究”

 4. 北京大学综合性创新药物研究技术大平台新药品种“嘧啶酮类抗HIV药物的临床前研究”

5. 北大方正创新药物研究基金“抗HIV药物的研发”

6. 国家重点实验室自主课题“抗HBV药物的研究”

代表性论文：

1. Amin Li, Yabo Ouyang, Ziyun Wang, Yuanyuan Cao, Xiangyi Liu, Li Ran, Chao Li, Li Li, Liang Zhang, Kang Qiao, Weisi Xu, Yang Huang, Zhili Zhang, Chao Tian, Zhenming Liu, Shibo Jiang, Yiming Shao, Yansheng Du, Liyang Ma*, Xiaowei Wang*, and Junyi Liu*  Novel Pyridinone Derivatives As Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI-Resistant HIV-1 Strains . Journal of Medicinal Chemistry,56, 3593-3608, 2013.

2. Xiaowei Wang^#, Jianfang Zhang^#, Yang Huang^#, Ruiping Wang, Liang Zhang, Kang Qiao, Li Li, Chang Liu, Yabo Ouyang, Weisi Xu, Zhili Zhang, Liangren Zhang, Shibo Jiang, Yimin Shao, Liying Ma* and Junyi Liu*. Design, Synthesis and Biological Evaluation of 1-[(2-benzyloxyl/alkoxyl) methyl]-5-halo-6–aryl uracils as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Drug Resistance Profile. Journal of Medicinal Chemistry,55, 2242-2250, 2012.

3. Xianling Ning, Ying Guo, Xiaowei Wang, Xiaoyan Ma, Chao Tian, Xueqi Shi, Renzong Zhu, Can Cheng, Yansheng Du, Zhizhong Ma,  zhili Zhang,* and Junyi Liu* Design, Synthesis, and Biological Evaluation of (E)？3,4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents.J. Med. Chem. 2014,57, 4302？4312.

4. Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Bernard T. Golding, Roger J. Griff,  Yansheng  Du, Junyi Liu*. Mechanism-based Design, Synthesis and Biological Studies of N5-Substituted Tetrahydrofolate Analogues as Inhibitors of Cobalamin-dependent Methionine Synthase and Potential Anticancer Agents. Euro. J. Med. Chem.58，228-236, 2012

5. Yuanyuan Cao, Yu Zhang, Shaotong Wu, Quanzhi Yang, Xuefeng Sun, Jianxiong Zhao, Fen Pei, Ying Guo , Chao Tian , Zhili Zhang , Haining Wang, Liying Ma, Junyi Liu*, Xiaowei Wang*. Synthesis and biological evaluation of pyridinone analogues as Novel potent HIV-1 NNRTIs. Bioorg. Med. Chem. 23 (2015) 149–159.

6. Yu Zhang, Xuefeng Sun,Ningning Fan,Jianxiong Zhao,Jing Tu,Xiangmei Chen,Junyi Liu* and Xiaowei Wang*. 5-Iodo-2-arylalkyl thio-6-aryl pyrimidin-4(3H)-ones as non-nucleoside anti-HBV agents. Med. Chem. Commun., 2015, 6, 1438–1443

7. Shaotong Wu, Qianqian Yin, Liang Zhao, Ningning Fan, Xiaowan Tang, Jianxiong Zhao, Tao Sheng, Ying Guo, Chao Tian, Zhili Zhang, Weisi Xu, Zhenming Liu, Shibo Jiang, Liying Ma,* Junyi Liu* and Xiaowei Wang*, A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2 (2H)-ones as potency inhibitors of HIV-1 variants. Org. Biomol. Chem.2015,  DOI: 10.1039/c5ob02154e

8. Weisi Xu,Jianxiong Zhao, Jianping Sun, Qianqian Yin,Yan Wang, Yang Jiao, Junyi Liu, ShiboJiang, Yiming Shao, Xiaowei Wang,* and Liying Ma.* The HEPT analogue, 1-((benzyloxy) methyl)-6-(3, 5-dimethylbenzyl)-5- iodopyrimidine-2, 4(1H, 3H)-dione (WPR-6), is active against a broad spectrum of HIV-1 strains of different subtypes with drug-resistance. Antimicrob. Agents Chemother.  2015, 59:8  4882-4888

9. Tong-Bo Zhang,Yuan-Yuan Cao, Shao-Tong Wu, Yu Zhang, Ying Guo,Jian-Xiong Zhao, Xue-Feng Sun,Quan-Zhi Yang,Zhi-Li Zhang, Chao Tian, Jun-Yi Liu^]*and Xiao-Wei Wang.^*An approach to synthesis of pyrimido[b]azepines via Ruthenium-catalyzed ring-closing metathesis. Synthesis 2015, 47, 3292–3300

10. Zhang Tongbo, Wu Shaotong, Cao Yuanyuan, Fu Yuhong, Guo Ying, Zhang Liang, Li Li, Zhou Han, Liu Xiangyi, Li Chao, Tang Xiaowan, Zhang Zhili, Tian Chao, Wang Xiaowei*,Liu Junyi*. Rapid Access to 10-(Cyclohexylimino)-7,9-diazaspiro[4.5]decane-6,8-dione Derivatives for HIV-1 Reverse Transcriptase Inhibition via Ruthenium-Catalyzed Ring-Closing Metathesis . Synthesis. 45, 2273-2279,2013.

11. Liang Zhang, Xiaowan Tang, Yuanyuan Cao, Shaotong Wu, Yu Zhang , Jianxiong Zhao, Ying Guo, Chao Tian , Zhili Zhang , Junyi Liu,* and Xiaowei Wang*. Synthesis and Biological Evaluation of Novel 2-Arylalkylthio-5-iodine-6-substituted- benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor. Molecules 2014, 19, 7104-7121.

12. Yang Huang# , Xiaowei Wang#, Xiaoling Yu, Lin Yuan, Ying Guo, Weisi Xu, Tiejun Liu, Junyi Liu, Yiming Shao* and Liying Ma*.Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors. Virology Journal, 8, 230-236, 2011.

13. Gong Li, Xiaowei Wang*, Chao Tian, Tongbo Zhang, Zhili Zhang, Junyi Liu*. Rapid access to multi-substituted pyrimido[4,5-b][1,4] diazepine-2,4,6-trione and pyrimido[4,5-b][1,4]diazepine-2,4-dione as novel and versatile scaffolds for drug discovery. Tetrahedron Letters53 (2012) 5193–5196.

14. Hua Qin, Jianfang Zhang, Chang Liu, Ying Guo, Siwei Zhang, Zhili Zhang, Xiaowei Wang, Liangren Zhang, Junyi Liu*, Synthesis and biological evaluation of novel 2-arylalkylthio-4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors, Bioorganic Medicinal Chemistry Letter. 20 , 3003–3005, 2010

15. Hua Qin, Chang Liu, Ying Guo, Ruiping Wang, Jianfang Zhang, Liying Ma, Zhili Zhang, Xiaowei Wang, Yuxin Cui, Junyi Liu*. Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry2010, 18: 3231–3237.

16. Xiao Lu, Yanli Chen, Ying Guo, Zhenming Liu, Yawei Shi, Yang Xu, Xiaowei Wang and Junyi Liu, The Design and Synthesis of N-1 alkylated 5-aminoaryalkyl substituted 6-methyluracils as potential non-nucleoside HIV-1 RT Inhibitors Bioorganic Medicinal Chemistry15 (2007) 7399–7407

17. Xiaowei Wang, Qinghua Lou, Ying Guo, Yang Xu, Zhili Zhang and Junyi Liu，The design and synthesis of 9-phenylcyclohepta[d] pyrimidine-2, 4-dione derivatives as potent non- nucleoside inhibitors of HIV reverse transcriptase.Organic & Biomolecular Chemistry2006, 4, 3252–3258

18. Li Li, Liying Ma, Xiaowei Wang*, Junyi Liu*. New efficient and flexible synthetic route to Emivirine and its analogs.Journal of Heterocyclic Chemistry, 50, 164-168, 2013.

19. 谢欣，王孝伟*，刘俊义*。免疫途径抗HIV信号通路: cGAS-STING研究进展。国际药学研究杂志，2014年10月，底41卷，第5期，525页。

授权专利：

1. 王孝伟；张建芳；刘俊义  新型HEPT类HIV-1逆转录酶抑制剂的制备及其应用  授权：ZL 201010208308.7中国发明专利（2014）

2. 李阿敏；王孝伟；马丽英；邵一鸣；刘俊义  新型吡啶酮类HIV-1逆转录酶抑制剂的制备及其应用  授权：ZL 201010515280.1  中国发明专利（2014）

3. 李立；高宇；王孝伟；刘俊义。  6-苄基-1-乙氧甲基-5-异丙基脲嘧啶(Emivirine)及其类似物的新合成方法。  授权：ZL 201010136763

4. 刘俊义，宁显玲，张志丽，郭莹，王孝伟，田超，E-3,4-二羟苯乙烯基磺酰胺磺酸酯类化合物的制备方法及其作为神经保护药物的应用。授权：ZL201310017346.8，发明专利       （2015）

申请专利：

1. 刘俊义，张亮，王孝伟，具有抗HBV病毒且兼具抗HIV和HCV病毒作用的新一类非核苷S-DABOs嘧啶酮衍生物的制备和应用，2012/ 08/10, 中国专利：201210531716.5

2. 刘俊义，王孝伟，曹源源，张志丽，郭莹，田超，3,4-二取代-6-苯乙基吡啶酮类HIV-1逆转录酶抑制剂的制备及其应用，2014/04/15：中国专利：201410154784.3。

3. 刘俊义；李超；王孝伟；张志丽；郭莹；田超，HIV逆转录酶/整合酶双靶点抑制剂6-苯甲酰基取代尿嘧啶类化合物的制备及应用，2013/04/08, 中国专利：201310142963.0

4. 王孝伟；刘俊义；张羽，2,5,6位取代嘧啶酮衍生物的制备方法及其作为抗乙肝病毒药物的应用，申请号: 201510183688.6

5. 王孝伟，刘俊义，赵剑雄，2-芳基硫代-5-碘代嘧啶酮类衍生物的制备方法及其作为抗乙肝病毒药物的应用，申请号:  201510183689.0